Dynamin and endocytosis
Dynamin is a GTPase responsible for endocytosis in the eukaryotic cell. Dynamin is part of the "dynamin superfamily", which includes classical dynamins, dynamin-like proteins, Mx proteins, OPA1, mitofusins, and GBPs. Members of the dynamin family are principally involved in the scission of newly formed vesicles from the membrane of one cellular compartment and their targeting to, and fu… WebAug 1, 2002 · Beyond dynamin's role in endocytosis. Although the role of dynamin in endocytosis is well established, novel data strongly suggest that this unusual GTPase plays multiple roles in the cell. Originally, it was shown that the ubiquitously expressed isoform dynamin 2 activates the transcription factor p53 and induces apoptosis in HeLa …
Dynamin and endocytosis
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WebDynamin 1 mediates the majority of synaptic vesicle endocytosis (SVE), particularly during a depolarization stimulus (Anggono and Robinson, 2009; Clayton et al., 2009) where dynamin 1 and several other endocytic proteins are constitutively phosphorylated in resting synapses and upon nerve stimulation. WebHere, using pharmacological inhibitors, siRNA-mediated silencing, or expression of mutant proteins, we showed that dynamin 2 (DNM2), the small GTPase Rab5 and the endocytosis receptor LDL receptor-related protein 1 (LRP-1), contribute significantly to gefitinib-mediated EGFR endocytosis in glioma cells.
WebFeb 1, 2024 · Dynamin is a GTPase that plays a vital role in clathrin-dependent endocytosis and other vesicular trafficking processes by acting as a pair of molecular … WebCollectively, these results indicate that cell–cell fusion involves dynamin and the formation of invadosome-like actin-rich protrusions associated with clathrin-mediated endocytosis. …
Web8 minutes ago · Dynamin-related protein (Drp1), a large GTPase, has been found to play an implicit role in the process of mitochondrial fission by catalyzing membrane pinching and produces an action similar to vesicle endocytosis and peroxisomal fission. WebDec 2, 2024 · These studies identified a genetic interaction between awd and dynamin (shi). 65 An aberrant endocytosis was associated with mutant awd phenotypes and complemented RAB5 or shi genes. 65,66,67 It ...
WebApr 4, 2024 · dynamin-independent endocytosis events [31, 32] and may have some role in breast cancer [ 156 ]. However, their exact role in the endocytic process is not clear, as they may be implicated
WebOct 13, 2014 · Using an inducible knockout mouse model to generate dynamin 1- and 2-deficient primary osteoclast precursors and myoblasts, we found that fusion of both cell … sharegate sharepoint migration limitationsWeb21 hours ago · Dynamin-2 haplodeficient female mice develop neutropenia with aging.Neutropenia is because of defective production from dysmyelopoiesis and … poor blood flow to legs medical termWebJan 18, 2024 · Dynamin 1 mediates the majority of synaptic vesicle endocytosis (SVE), particularly during a depolarization stimulus (Anggono and Robinson, 2009; Clayton et al., 2009) where dynamin 1 and several other endocytic proteins are constitutively phosphorylated in resting synapses and upon nerve stimulation. sharegate set permissionsWebJan 3, 2024 · A. Endocytosis; B. Exocytosis; Endocytosis is a mechanism for internalizing large extracellular molecules (e.g., proteins), insoluble particles, or even microorganisms. The three main types of exocytosis are phagocytosis, pinocytosis and receptor-mediated endocytosis.Pinocytosis is non-specific. Phagocytosis targets large structures (e.g., … sharegate sharepoint migration issuesWebDynamin is a key GTPase involved in various forms of endocytosis and is comprised of 3 major isoforms, all of which have four main functional domains. In addition to being a key component of endocytosis, … sharegate sharepoint migrationWebNov 15, 2006 · Dynamin is a GTPase that plays a key role in the endocytic scission process in mammalian cells (Song and Schmid, 2003). Although dynamin relatives are present in yeast, there is no experimental support for a role for this family of proteins in endocytosis (Engqvist-Goldstein and Drubin, 2003). Alternatively, in the absence of amphiphysins ... sharegate sgum fileWebNov 1, 2024 · Dynamin as an important endocytosis-related protein has been extensively studied, especially in neurons (Antonny et al., 2016; Fan et al., 2016; Raimondi et al., 2011). However, the expression patterns of dynamin isoforms and their roles in clathrin-dependent endocytosis in non-neuronal cells are still incompletely understood. In this study ... sharegate sharepoint tool